As shown in the diagram below, NMN combines with ATP to form NAD+. Having more NMN molecules in our body may mean we can create more NAD+.

NAD+ is the second most abundant molecule in the body (water is #1). Without it, our health would be greatly impacted.

NAD+ is involved in the following vital processes:

• DNA repair
• Cellular energy
• Sensory & motor function
• Sirtuin activation
• Heart health
• Kidney health
• Glucogenesis in the liver
• Insulin secretion
• Fatty acid oxidation
• Healthy immune response
• Endothelial function

NAD+ is vital for life. Unfortunately, NAD+ level steadily decline with age. It is thought that by the time we reach middle age, our levels of NAD+ have fallen to half of our youthful levels.

Some scientists believe that the lack of NAD+ leads to increased DNA damage, which can lead to complications of aging, including brain fog, muscle wasting, and fatigue, among other things.

NAD+ is necessary for PARP1, a vital DNA repair protein, to function. NAD+ is also vital for the activation of sirtuins, proteins that are known as "gene guardians" and are vital for cellular homeostasis. Sirtuins participate in cellular stress responses, damage repair, insulin secretion, and many other vital processes in the body.

NAD+ plays an active role in all metabolic processes, but is heavily involved in the production of cellular energy. The presence of NAD+ increases cellular energy, vital for enzyme activity, gene expression, and cell signaling.

Evidence suggests that increasing NAD+ levels naturally through NMN supplementation may slow certain aging processes.

Scientists have determined that when the body is subjected to external stressors, such as overexposure to the Sun (UV radiation), strenuous exercise, pollution, and the general effects of aging, our DNA is damaged. Such cumulative DNA damage has been scientifically confirmed as the cause of age-related decline.

In a series of over 30 peer-reviewed scientific and clinical studies conducted by third party laboratories and university medical centers, AC-11® has been proven to:

• Support the body’s natural ability to repair its own DNA.
• Support a healthy immune system.
• Help to normalize the expression of NF-KB, which may help to regulate cellular response to systemic inflammation.
• Maintain telomere length and integrity during the process of cellular mitosis.
• Increase natural collagen III production, which is the form of collagen associated with soft, supple, youthful-looking skin.

For more information about the clinically-proven benefits of AC-11®, visit: https://www.optigenex.com/oral-studies

In-vivo (living) studies show that AC-11® enhances DNA repair through the elevation of serum thiol levels. Serum thiols are antioxidative proteins found in the blood that neutralize free radicals.

Free radicals are highly reactive atoms or molecules that can impede DNA repair enzymes and cause DNA damage. Higher levels of serum thiols reflect an enhanced ability to repair DNA.

Source: Yezhou Sheng et al., Induction of Apoptosis and Inhibition of Proliferation in Human Tumor Cells Treated with Extracts of Uncaria Tomentosa (Anticancer research 1998).

AC-11® is extracted from Uncaria Tomentosa by an exclusive hot water extraction process, and is then micro-filtered and purified in order to obtain Carboxyl Alkyl Esters (CAE), which are responsible for at least 90% of the ingredient's therapeutic benefits. This process yields a distinct molecular composition of a low weight, bioavailable, scientifically indole alkaloid free extract.

AC-11® is different to other forms of Uncaria Tomentosa because research has shown it to be safe and effective. The recommended daily dosage of AC-11® is 700mg, which can be found in 4 capsules of Retra NAD+ Booster.

Each serving of 4 capsules contains 500mg of NMN and 700mg of AC-11®, designed to provide exceptional and noticeable results.

Yes! Both NMN and AC-11 have been studied for years to show their positive effects.

For best results, we recommend taking 4 capsules per day. However, you will experience positive results with just two capsules per day.

We source our ingredients from all over the world and ship them to our Texas-based manufacturing facility.